Karl Pearson:
RA Fisher:
Now, if you are going to take Darwinism as your theory of life and apply it to human problems, you must not only believe it to be true, but you must set to, and demonstrate that it actually applies. […] It was not a light task, but it gave for many years the raison d’etre of my statistical work.
Pearson, 1912, in ‘Darwinism, Medical Progress and Eugenics’. Eugenics Laboratory Lecture Series, IX
PSA: eugenics is a bunch of bullshit
caused by Mycobacterium tuberculosis
occurs more often among relatives
major risk factors: silicosis (30x), malnutrition, smoking, alcoholism, crowding
minor: genetics (mostly immune-related)
Pearson: it’s hereditary!
Hill & Doll: retrospectively compare cancer rates between matched smoking/nonsmoking pairs
Hill & Doll: prospectively compare cancer rates between smoking/nonsmoking doctors
etcetera
Fisher: Correlation is not causation. Let’s calmly study this a while longer.
Pearson & Fisher had a big impact in part because (they were pushy and) they were working towards something.
Today we have many problems that we need quantitative work to solve.
Where do you want to have an impact?